COMPARISON OF MORPHINE AND SUBLINGUAL BUPRENORPHINE FOLLOEING ABDOMINAL SURGERY

In a prospective Study, patients undergoing abdominal surgery were allocated randomly to receive intermittent morphine lOmgi.m. (n —41) or a lingle injection of buprenorphine 0.3 mgi.m. followed by sublingual buprenorphine 0.4 mg every 6h (n=39) for 3 days following operation. Patients receiving bup...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1984-08, Vol.56 (8), p.855-859
Main Authors: CUSCHIERI, R.J., MORRAN, C.G., MCARDLE, C.S.
Format: Article
Language:English
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Summary:In a prospective Study, patients undergoing abdominal surgery were allocated randomly to receive intermittent morphine lOmgi.m. (n —41) or a lingle injection of buprenorphine 0.3 mgi.m. followed by sublingual buprenorphine 0.4 mg every 6h (n=39) for 3 days following operation. Patients receiving buprenorphine were allowed additional morphine, if required. Pain (cores (linear analogue scale) in those patients receiving regular sublinguftl buprenorphine were consistently less than in those receiving intermittent morphine i.m. Half the patients receiving buprenorphine required no additional analgesia; only 15% required additional armigi-nin after the first day following operation. Arterial blood-gas analyses showed m’gnrfirant hypozaemU and significantly greater carbon dioxide tensions in those receiving buprenorphine. These results suggest that a regimen based on the use of sublingual buprenorphine provides pain relief comparable to that provided by intermittent opiates
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/56.8.855