P391 The availability of anti-TNF agents is associated with reduced early surgical requirements in Crohn’s disease but not in ulcerative colitis. A nationwide study from the Eneida registry

• Published in: Journal of Crohn's and colitis 2018-01, Vol.12 (supplement_1), p.S301-S302
• Main Authors: Guasch, M, Clos, A, Ordás, I, García-Sánchez, V, Gisbert, J P, Taxonera, C, Vera, I, Mínguez, M, Guardiola, J, López-Sanromán, A, Rivero-Tirado, M, Nos, P, Gomollón, F, Carbajo, A Y, de Francisco, R, Martín-Arranz, M D, Garcia-Planella, E, García-López, S, de Castro, L, Calvet, X, Camargo, R, Esteve, M, Sicilia, B, Andreu, M, Macho, A, Piqueras, M, Bermejo, F, Gutiérrez, A, Busquets, D, Martínez-Montiel, P, Hinojosa, J, Pérez-Calle, J L, Bujanda, L, Rodríguez-Pérez, A, Lorente, R, Jiménez, N, Navarro-Llavat, M, Cabriada, J L, Camo, P, Van Domselaar, M, Rodríguez-González, E, Rodríguez-Gutiérrez, C, Huguet, J M, Lucendo, A J, Argüelles, F, Almela, P, Merino, O, Calafat, M, Ogueta, M, Charro, M, Llaó, J, Muñoz, C, Ramos, L, Abad, Á, Roncero, Ó, Barreiro-de-Acosta, M, Sesé, E, Mañosa, M, Domènech, E
• Format: Article
• Language: English
• ISSN: 1873-9946; 1876-4479
• DOI: 10.1093/ecco-jcc/jjx180.518

Abstract Background It has been suggested that biological therapies might change the natural history of IBD, avoiding surgery in a proportion of patients. Retrospective series show controversial results and include small samples sizes. Methods To assess the impact of the availability of anti-TNF agents on the need for early surgery (within the first 5 years from IBD diagnosis) in both CD and UC, all those incident patients who were diagnosed in two different periods (before and after anti-TNF availability) were identified from the ENEIDA Registry (a large, prospectively maintained database of the Spanish Working Group in IBD –GETECCU-). Incident cohorts included the time periods 1990–1995 and 2007–2012 for CD, and 1995–2000 and 2007–2012 for UC. Patients lacking dates of IBD diagnosis or surgery, as well as those with a follow-up