P1554Is self-reported sleep-disordered breathing associated with increased cardiovascular risk?

• Published in: European heart journal 2019-10, Vol.40 (Supplement_1)
• Main Authors: Korostovtseva, L, Rotar, O, Alieva, A, Bochkarev, M, Boyarinova, M, Zvartau, N, Sviryaev, Y U, Konradi, A, Shlyakhto, E
• Format: Article
• Language: English
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/eurheartj/ehz748.0314

Abstract Background Sleep-disordered breathing (SDB) is associated with the increased cardiovascular (CV) morbidity and mortality. However, sleep apnea is not considered in the standard scales used for the risk stratification. Purpose We evaluated the association between self-reported SDB and SCORE risk (the 10-year risk of fatal CV events according to the systemic coronary risk evaluation) in the population-based sample from St Petersburg. Methods We selected 1555 subjects without previously known CV events (550 males, 35%; mean age 46.7±11.6 years old) out of 1600 participants of the population-based sample (from the epidemiological study ESSE-RF, St Petersburg). All subjects were interviewed (questions about lifestyle, medical history, complaints) using standard questionnaire. We assessed self-reported snore (“Do you snore?”) and sleep apnea (“Do you have sleep apneas?”). Affirmative response was considered diagnostic. Daytime sleepiness was assessed based on the answers >3 times/week to the question “How often have you been unable to refrain sleeping when required?”. The 10-year risk of fatal CV events was assessed by the SCORE high-risk charts calculator. For statistical analysis we used parametric statistics, frequency and contingency analyses (Chi-square), multiple logistic regression analysis (stepwise inclusion; the parameters not evaluated in the SCORE scale were considered, i.e. body mass index, glucose level, triglyceride, HDL-cholesterol, creatinine, C-reactive protein, self-reported insomnia). Results Based on the SCORE assessment the participants were divided as following: low risk (