P100 INCREASING RATES OF INFECTIVE ENDOCARDITIS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

• Published in: Inflammatory bowel diseases 2019-02, Vol.25 (Supplement_1), p.S48-S49
• Main Authors: Shah-Khan, Sardar M, Kupec, Justin
• Format: Article
• Language: English
• ISSN: 1078-0998; 1536-4844
• DOI: 10.1093/ibd/izy393.108

Abstract Background Infective endocarditis (IE) is a rare but reported extraintestinal manifestation of inflammatory bowel disease (IBD). In addition to several case reports, there are small level retrospective studies that have suggested that IBD may be an independent risk factor for the development of IE. Patients with IBD are often immunosuppressed and undergo multiple procedures that render them susceptible to bacteremia and, subsequently, endocarditis. Despite this, there is a lack of evidence regarding the association of IE and IBD and no estimates of disease burden. We aim to estimate the burden of infective endocarditis in patients with inflammatory bowel disease using a national level database. Methods We queried the National Inpatient Sample (NIS) for all hospitalizations of patients with a primary or secondary diagnosis of IBD [Crohn’s disease (CD) or ulcerative colitis (UC)] with or without a diagnosis of infective endocarditis using the International Classification of Diseases Ninth Edition Clinical Modification (ICD-9 CM) codes from 2003-2014. We then conducted a retrospective cohort study and performed statistical analysis using SPSS (version 25.0). Trend analysis was tested using Mann-Kendall trend test and associations were evaluated using multivariate logistic regression. Results From 2003-2014, there were a total of 5215 hospitalizations (3165 in CD and 2050 in UC) for IE in patients with IBD. The patients were primarily Caucasians (69.3% in CD and 70.8% in UC) with an age greater than 61 (49.6 % in CD and 60.1% in UC). In patients with CD and IE, they were primarily female (56.5%) while those with UC and IE were primarily males (52.2%). The rate of IE in IBD was found to be significantly rising (12.9 cases per 10000 hospitalizations in 2003 to 20.5 in 2014; p