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B-type natriuretic peptide predicts deterioration in functional capacity following lung resection

Following lung resection, there is a decrease in the functional capacity and quality of life, which is not fully explained by changes in pulmonary function. Previous work demonstrates that B-type natriuretic peptide (BNP) is associated with short- and long-term complications following lung resection...

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Bibliographic Details
Published in:Interactive cardiovascular and thoracic surgery 2019-06, Vol.28 (6), p.945-952
Main Authors: Young, Douglas J, McCall, Philip J, Kirk, Alan, Macfie, Alistair, Kinsella, John, Shelley, Benjamin G
Format: Article
Language:English
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Summary:Following lung resection, there is a decrease in the functional capacity and quality of life, which is not fully explained by changes in pulmonary function. Previous work demonstrates that B-type natriuretic peptide (BNP) is associated with short- and long-term complications following lung resection, leading to the suggestion that cardiac dysfunction may contribute to functional deterioration. Our aim was to investigate any relationship between BNP and subjective and objective indices of functional deterioration following lung resection surgery. Twenty-seven patients undergoing lung resection had serum BNP measured preoperatively, on postoperative day (POD)1 and POD2, and at 2 months postoperatively. The functional deterioration was assessed using 6-min walk tests and the Medical Research Council dyspnoea scale. 'Deterioration in functional capacity' was defined as either an increase in the Medical Research Council dyspnoea score or a significant decrease in the 6-min walk test distance. BNP increased over time (P 
ISSN:1569-9285
1569-9285
DOI:10.1093/icvts/ivz016