Etiology and Antimicrobial Therapy of Acute Maxillary Sinusitis

Eighty-one adults with symptoms of acute sinusitis were studied by direct needle puncture and aspiration of the maxillary sinus (105 sinuses). Fifty-nine bacterial strains were isolated in titers of ⩾104 colony-forming units/ml; Streptococcus pneumoniae and Haemophilus influenzae accounted for 64% o...

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Bibliographic Details
Published in:The Journal of infectious diseases 1979-02, Vol.139 (2), p.197-202
Main Authors: Hamory, Bruce H., Sande, Merle A., Sydnor, Austin, Seale, Daniel L., Gwaltney, Jack M.
Format: Article
Language:English
Subjects:
Adult
Amoxicillin - therapeutic use
Ampicillin - therapeutic use
Anaerobic bacteria
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antimicrobials
Bacteria - isolation & purification
Haemophilus Infections - microbiology
Haemophilus influenzae - isolation & purification
Humans
Infections
Major Articles
Maxillary sinus
Maxillary Sinus - microbiology
Neisseria
Sinuses
Sinusitis
Sinusitis - diagnosis
Sinusitis - drug therapy
Sinusitis - microbiology
Streptococcal Infections - microbiology
Streptococcus
Streptococcus pneumoniae - isolation & purification
Sulfamethoxazole - therapeutic use
Trimethoprim - therapeutic use
Viruses
Viruses - isolation & purification
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Summary:Eighty-one adults with symptoms of acute sinusitis were studied by direct needle puncture and aspiration of the maxillary sinus (105 sinuses). Fifty-nine bacterial strains were isolated in titers of ⩾104 colony-forming units/ml; Streptococcus pneumoniae and Haemophilus influenzae accounted for 64% of the isolates. Other bacteria recovered included anaerobes (12%), Neisseria species (8.5%), Streptococcus pyogenes (3%), α-hemolytic Streptococcus (3%), non-group A β-hemolytic Streptococcus (3%), Staphylococcus aureus (2%), Pseudomonas aeruginosa (2%), and Escherichia coli (2%), Viruses were isolated from 11 sinuses; these isolates included rhinovirus (six). influenza A (H3N2) virus (three), and two types of parainfluenza virus (one each). The efficacy of therapy with orally administered ampicillin. amoxicillin, or trimethoprim-sulfamethoxazole was evaluated by a repeat sinus puncture and culture. Clinical and bacteriologic responses to all three regimens were good.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/139.2.197