Cefoxitin sodium: a clinical and pharmacological study

In a clinical study, predominantly of patients with intra-abdominal sepsis, 14 (70%) of 20 patients were cured by cefoxitin sodium i.v. A further 6 (30%) patients improved. There were no clinical failures. Cefoxitin appears to possess the safety of the cephalosporins and penicillins, although a tran...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1978-01, Vol.4 (suppl-B), p.155-160
Main Authors: Reeves, D. S., Bint, A. J., Holt, H. A., Stocks, P. J.
Format: Article
Language:English
Subjects:
Adult
Aged
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Cefoxitin - adverse effects
Cefoxitin - blood
Cefoxitin - therapeutic use
Cephalosporins - therapeutic use
Child
Clinical Trials as Topic
Drug Interactions
Female
Humans
Male
Middle Aged
Probenecid - pharmacology
Time Factors
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Summary:In a clinical study, predominantly of patients with intra-abdominal sepsis, 14 (70%) of 20 patients were cured by cefoxitin sodium i.v. A further 6 (30%) patients improved. There were no clinical failures. Cefoxitin appears to possess the safety of the cephalosporins and penicillins, although a transient, slight disturbance of liver function was seen in 25% of the patients and phlebitis also occurred in 25%. No adverse effects on renal function were seen. In patients with normal renal function, cefoxitin is rapidly cleared from the blood. Administration of probenecid raises the blood levels of cefoxitin and prolongs their duration. Cefoxitin is likely to be a valuable agent in a variety of infections, particularly gut-associated sepsis. Dose schedules must now be defined, particularly for children and seriously ill patients.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/4.suppl_B.155