Gross tumor volume in sinonasal tract cancer as a predictor of local recurrence after chemoradiotherapy

• Published in: Japanese journal of clinical oncology 2018-12, Vol.48 (12), p.1041-1045
• Main Authors: Suzuki, Hidenori, Kimura, Kana, Kodaira, Takeshi, Tachibana, Hiroyuki, Tomita, Natsuo, Koide, Yutaro, Tanaka, Hiroshi, Nishikawa, Daisuke, Koide, Yusuke, Beppu, Shintaro, Hanai, Nobuhiro
• Format: Article
• Language: English
• Subjects: Carcinoma, Squamous Cell - complications; Carcinoma, Squamous Cell - pathology; Carcinosarcoma - complications; Carcinosarcoma - pathology; Chemoradiotherapy - adverse effects; Chemoradiotherapy - methods; Female; Head and Neck Neoplasms - complications; Head and Neck Neoplasms - pathology; Humans; Male; Middle Aged; Neoplasm Recurrence, Local - pathology; Nose Neoplasms - complications; Nose Neoplasms - pathology; Prognosis; Retrospective Studies; Teratoma - complications; Teratoma - pathology; Tumor Burden - genetics
• ISSN: 1465-3621; 1465-3621
• DOI: 10.1093/jjco/hyy147

This study investigated whether gross tumor volume of the primary tumor before treatment was a predictor for local recurrence in patients with resectable sinonasal tract squamous cell carcinoma who were treated by chemoradiotherapy. A total of 24 patients were enrolled. Pretreatment gross tumor volume of primary tumor was assessed by palpitation, perception and imaging. The cut-off value of the gross tumor volume for local recurrence was determined by receiver-operating curve analysis. A log-rank test and Cox's proportional hazards model were used for univariate and multivariate analyses with adjustment for the clinical T category (cT1-T4a/cT4b), respectively. In the univariate analysis, patients with the gross tumor volume ≥83.7 ml were significantly associated with shorter local recurrence-free rate (P = 0.0023) and disease-free survival (P = 0.0064) than those with gross tumor volume