Failure off Inoculation With Polyoma Virus To Influence Chemical Carcinogenesis in Mice

Because inoculation with the polyoma virus will protect adult mice against growth of a relatively small number of cells of transplantable polyoma-induced tumors and because the immunity apparently is not due to the virus per se but to an altered cell antigen, it seemed pertinent to determine whether...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1963-01, Vol.30 (1), p.203-206
Main Authors: Malmgren, Richard A., Rabson, Alan S.
Format: Article
Language:English
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Summary:Because inoculation with the polyoma virus will protect adult mice against growth of a relatively small number of cells of transplantable polyoma-induced tumors and because the immunity apparently is not due to the virus per se but to an altered cell antigen, it seemed pertinent to determine whether inoculation with the polyoma virus would also protect against chemical carcinogenesis. C3H/HeN female mice, treated with 3-methylcholanthrene by subcutaneous injection or skin painting, developed the same number of tumors and at the same rate in polyoma-virus infected and uninfected animals. A/LN male mice treated with urethan developed the same number of lung tumors in polyoma-virus infected and uninfected animals. Polyoma virus infection therefore did not interfere with or protect against chemical carcinogenesis.
ISSN:0027-8874
1460-2105
1460-2105
DOI:10.1093/jnci/30.1.203