The recognition of Z-DNA by chiral helicene

Enantiomeric helicenes of (P)-A and (M)-A were synthesized. The binding of the helicenes to B- and Z-DNA was studied quantitatively by CD, equilibrium dialysis, and fluorescence spectroscopy. Enantiomeric (P)-A not only bound selectively to Z-DNA, but also effectively converted the B-DNA conformatio...

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Bibliographic Details
Published in:Nucleic Acids Symposium Series 2004-11, Vol.48 (1), p.87-88
Main Authors: Xu, Yan, Sugiyama, Hiroshi, Tanaka, Kazuhiko, Osuga, Hideji
Format: Article
Language:English
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Summary:Enantiomeric helicenes of (P)-A and (M)-A were synthesized. The binding of the helicenes to B- and Z-DNA was studied quantitatively by CD, equilibrium dialysis, and fluorescence spectroscopy. Enantiomeric (P)-A not only bound selectively to Z-DNA, but also effectively converted the B-DNA conformation to Z-DNA. The enantio-selectivity of the helicenes offers a new route for the rational design of inhibitors of biological functions that may depend on Z-DNA.
ISSN:0261-3166
1746-8272
DOI:10.1093/nass/48.1.87