Quantitative bone scanning in the diagnosis of aluminium osteomalacia

Skeletal uptake of diphosphonate was measured by emission tomography in 30 patients on chronic dialysis treatment. In 19 patients mean plasma aluminium concentrations, measured over the preceding 12 months, were 'high' (greater than 1.0 mumol/l, and in the other 11 were 'low' (le...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 1989, Vol.4 (8), p.721-724
Main Authors: WORTH, D. P, SMYE, S. W, ROBINSON, P. J, DAVISON, A. M, WILL, E. J
Format: Article
Language:English
Subjects:
Adult
Aged
Alkaline Phosphatase - blood
Aluminum - adverse effects
Aluminum - blood
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Bone and Bones - diagnostic imaging
Bone and Bones - metabolism
Diphosphonates
Emergency and intensive care: renal failure. Dialysis management
Female
Humans
Intensive care medicine
Male
Medical sciences
Middle Aged
Osteomalacia - blood
Osteomalacia - chemically induced
Osteomalacia - diagnostic imaging
Radioisotopes
Renal Dialysis - adverse effects
Tomography, Emission-Computed
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Summary:Skeletal uptake of diphosphonate was measured by emission tomography in 30 patients on chronic dialysis treatment. In 19 patients mean plasma aluminium concentrations, measured over the preceding 12 months, were 'high' (greater than 1.0 mumol/l, and in the other 11 were 'low' (less than 1.0 mumol/l). There was a strong correlation between serum alkaline phosphatase and skeletal uptake of diphosphonate in each group, but no difference in diphosphonate uptake between the groups. Additionally, when six patients with positive desferrioxamine tests were matched for serum alkaline phosphatase with six patients from the 'low' aluminium group there was no significant difference in uptake of diphosphonate (median and range 7.2; 5.2-16.5 and 5.9; 2.7-10.8 respectively). We conclude that skeletal uptake of diphosphonate is not suppressed in patients with moderate aluminium loading, but reflects bone turnover as indicated by serum alkaline phosphatase. Quantitative bone scintigraphy is not a useful discriminator for early aluminium osteomalacia.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/4.8.721