Acute cholecystitis after autologous bone marrow transplantation for acute myeloid leukemia

Background: We investigated the incidence of acute cholecystitis in patients with acute myeloid leukemia (AML) undergoing autologous bone marrow transplantation in complete remission. Patients and methods: Thirty-five consecutive acute myeloid leukemia patients were given oral busulfan4 mg/kg/day fo...

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Bibliographic Details
Published in:Annals of oncology 1995-03, Vol.6 (3), p.302-304
Main Authors: Kuttah, L., Weber, F., Creger, R. J., Fox, R. M., Cooper, B. W., Jacobs, G., Lazarus, H. M.
Format: Article
Language:English
Subjects:
Acute Disease
acute myeloid leukemia
Adult
autologous bone marrow transplant
Biological and medical sciences
Bone Marrow Transplantation
busulfan
Busulfan - adverse effects
Cholecystectomy
cholecystitis
Cholecystitis - chemically induced
Cholecystitis - surgery
cyclophosphamide
Cyclophosphamide - adverse effects
Drug toxicity and drugs side effects treatment
Female
Humans
Leukemia, Myeloid - therapy
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Retrospective Studies
Toxicity: digestive system
Transplantation, Autologous
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Summary:Background: We investigated the incidence of acute cholecystitis in patients with acute myeloid leukemia (AML) undergoing autologous bone marrow transplantation in complete remission. Patients and methods: Thirty-five consecutive acute myeloid leukemia patients were given oral busulfan4 mg/kg/day for 4 days and IV cyclophosphamide 50 mg/kg/day for 4 days followed by reinfusion of autologous bone marrow purged with 4-hydroperoxycyclophosphamide. Results: Five of 35 patients developed clinical evidence of acute cholecystitis, manifested by fever, nausea, vomiting, right-upper-quadrant pain, and abdominal guarding, within 18 days after autologous bone marrow infusion.Ultrasonography and CT scans of the abdomen supported the diagnosis of cholecystitis. Three patients underwent cholecystectomy, while two patients were treated medically; all recovered uneventfully. A review of 338 consecutive bone marrow transplant patients who underwent marrow transplantation for a variety of diseases and were treated with other high-dose cytotoxic regimens during the same time period revealed significantly fewer cases of cholecystitis, i.e. two, (p
ISSN:0923-7534
1569-8041
DOI:10.1093/oxfordjournals.annonc.a059163