Acute administration of triazolam for the daytime sleep of rotating shift workers

Ten rotating shift workers, who changed shifts every 1 to 4 weeks, slept in the laboratory during the first four daytime sleep periods of two consecutive tours of night shift. Prior to the first two sleep periods of one tour, the subjects were given 0.5 mg triazolam. Placebo was administered prior t...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 1984-01, Vol.7 (3), p.223-229
Main Authors: WALSH, J. K, MUEHLBACH, M. J, SCHWEITZER, P. K
Format: Article
Language:English
Subjects:
Adaptation, Physiological - drug effects
Adult
Anti-Anxiety Agents - therapeutic use
Biological and medical sciences
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Hypnotics. Sedatives
Male
Medical sciences
Middle Aged
Neuropharmacology
Occupational Diseases - drug therapy
Personnel Staffing and Scheduling
Pharmacology. Drug treatments
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rotation
Sleep Wake Disorders - drug therapy
Triazolam - therapeutic use
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Summary:Ten rotating shift workers, who changed shifts every 1 to 4 weeks, slept in the laboratory during the first four daytime sleep periods of two consecutive tours of night shift. Prior to the first two sleep periods of one tour, the subjects were given 0.5 mg triazolam. Placebo was administered prior to sleep periods one and two of the other night shift tour. Neither drug nor placebo was given before the third and fourth sleep period of either tour of night shift. Conditions were counterbalanced among subjects. Polysomnography demonstrated that triazolam significantly increased total sleep time and sleep efficiency relative to placebo, primarily by promoting sleep maintenance. No adaptation to daytime sleep was seen during the four consecutive sleep periods without triazolam (placebo, then no drug). Triazolam did not appear to promote adaptation to daytime sleep on the 2 days following triazolam administration.
ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/7.3.223