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Statin Treatment Attenuates Muscular and Cardiorespiratory Adaptations to Treadmill Training in Mice
Abstract only Individuals with hypercholesterolemia are at increased risk for developing heart disease and are often prescribed statins, the most effective cholesterol‐lowering drugs, as well as exercise. A highly reported side effect of statins is muscle pain and dysfunction that may be exacerbated...
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Published in: | The FASEB journal 2020-04, Vol.34 (S1), p.1-1 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | Abstract only Individuals with hypercholesterolemia are at increased risk for developing heart disease and are often prescribed statins, the most effective cholesterol‐lowering drugs, as well as exercise. A highly reported side effect of statins is muscle pain and dysfunction that may be exacerbated with exercise. However, we previously reported that muscle force and cardiorespiratory fitness were not negatively impacted by statin treatment during treadmill training in mice with genetically high cholesterol, ApoE −/− . Both exercise and statins have been associated with reduced inflammatory cytokines such as interleukin‐6 (IL‐6). To date, no studies have investigated if statin treatment in C57 mice (wild type control for ApoE −/− ) impacts muscular and cardiorespiratory adaptations to treadmill training. We hypothesized that statin treatment would negatively impact muscular and cardiorespiratory adaptations to treadmill training, and such impairments would be associated with higher inflammatory cytokine levels. Adult mice were divided into 4 groups (n= 8–10/group) and completed 14d of treadmill training (60 min/day) or remained sedentary while receiving daily placebo or atorvastatin. Cardiorespiratory adaptations were assessed by pre‐ and post‐maximal treadmill tests. Plantarflexor muscle force and fatigue (% of max force after 10 contractions) were measured in vivo . Muscle IL‐6 and vascular endothelial factor (VEGF) protein levels were quantified with ELISA. Data were analyzed with 2‐way ANOVAs and post‐hoc tests. Atorvastatin was associated with decreased maximal isometric force relative to body mass in treadmill groups only with no difference in sedentary groups (1.6±0.06 vs. 1.1±0.05 and 1.6±0.07 vs. 1.5±0.08 g/g body mass, respectively, p |
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ISSN: | 0892-6638 1530-6860 |
DOI: | 10.1096/fasebj.2020.34.s1.04595 |