Early Life Stress in Summer Months Accelerates the Progression of Autoimmunity in Female Lupus‐Prone Mice

Systemic lupus erythematosus (SLE) is a classic autoimmune inflammatory disorder in which a loss of tolerance causes over‐activation of B and T cells that results in autoantibody production. These “self‐attacking” autoantibodies [e.g., double‐stranded (ds) DNA autoantibodies] are a hallmark of SLE a...

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Bibliographic Details
Published in:The FASEB journal 2021-05, Vol.35 (S1), p.n/a, Article fasebj.2021.35.S1.04674
Main Authors: Hartman, Rusty, Mathis, Keisa
Format: Article
Language:English
Online Access:Get full text
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Summary:Systemic lupus erythematosus (SLE) is a classic autoimmune inflammatory disorder in which a loss of tolerance causes over‐activation of B and T cells that results in autoantibody production. These “self‐attacking” autoantibodies [e.g., double‐stranded (ds) DNA autoantibodies] are a hallmark of SLE and correlate with disease severity. Although it is thought that a mix of genetic, environmental, immunoregulatory, hormonal and/or epigenetic factors may initiate the autoimmune process, the exact cause of this aberrant immune activity is unknown. Our lab has worked with an established mouse model of SLE, the female NZBWF1 mouse, for over 10 years. Our SLE mice endure the stressful trek from Jackson Labs in Bar Harbor, ME to our campus in Fort Worth, TX early in life (
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.2021.35.S1.04674