Maternal Exercise May Improve Metabolic Outcomes in Offspring in Mice

Objective It is well recognized in both human epidemiological and animal studies that the maternal in utero environment has significant effects on development of offspring. This includes sedentary lifestyle, which has been linked to developmental programming of metabolic dysfunction. The aim of this...

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Bibliographic Details
Published in:The FASEB journal 2022-05, Vol.36 (S1), p.n/a
Main Authors: Prentice, Danielle M., Bingaman, Sarah, Ural, Serdar, Browning, Kirsteen, Arnold, Amy
Format: Article
Language:English
Online Access:Get full text
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Summary:Objective It is well recognized in both human epidemiological and animal studies that the maternal in utero environment has significant effects on development of offspring. This includes sedentary lifestyle, which has been linked to developmental programming of metabolic dysfunction. The aim of this study is to investigate metabolic outcomes in offspring of sedentary mice versus mice that exercised in pregnancy. Study Design C57BL/6J female mice were placed on a control diet and allocated to sedentary versus exercise cages at 17 weeks of age. Exercise cages included a voluntary running wheel, with daily exercise measured via activity trackers. Mice were allowed to exercise for 2 weeks prior to breeding and throughout weaning. Offspring underwent body composition measurement and insulin and glucose tolerance tests at 6 weeks of age. At 14‐16 weeks of age, body composition was reassessed and mice were euthanized for tissue collection. Outcomes were analyzed between sedentary (SED) and exercise (EX) offspring using an unpaired t‐test, with p
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.2022.36.S1.R3387