Characterization of regression of exercise‐induced cardiac hypertrophy

The heart is capable of changing size in response to changes in chronic stress or demand. Exercise and hypertension are classic examples of stimuli that promote physiologic and pathologic hypertrophy respectively. Although initially beneficial for maintaining function with increased stress, patholog...

Full description

Saved in:
Bibliographic Details
Published in:The FASEB journal 2010-04, Vol.24 (S1), p.lb593-lb593
Main Authors: Stricker, Janelle C, Nichols, Cody E, Katz, Andrew, Fancher, Ibra, Cuppett, Tiffany C, Miletti, Kady, Vasisko, Corey, Dabkowski, Erinne R, Baseler, Walter A, Hollander, John M, Morissette, Michael R
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The heart is capable of changing size in response to changes in chronic stress or demand. Exercise and hypertension are classic examples of stimuli that promote physiologic and pathologic hypertrophy respectively. Although initially beneficial for maintaining function with increased stress, pathologic hypertrophy can progress to heart failure if the inducing stress is not mitigated. Additionally, in contrast to physiologic hypertrophy, reverse remodeling of pathologic hypertrophy is often incomplete in respect to returning to normal size and function. In order to understand the molecular mechanisms involved in the reversal of hypertrophy we subjected mice to a three‐week swim protocol followed by 0, 3, and 6 days of rest. Swim‐training induced a 25.4±2.0% (n=19, p
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.24.1_supplement.lb593