Immune modulator effects of hydroalcoholic extract of Matricaria chamomilla in mouse macrophages

• Published in: The FASEB journal 2016-04, Vol.30 (S1)
• Main Authors: Torres‐Tirado, David, Leon‐Buitimea, Angel, Perez‐Flores, Gabriela
• Format: Article
• Language: English
• ISSN: 0892-6638; 1530-6860
• DOI: 10.1096/fasebj.30.1_supplement.lb166

Abstract only In México is common the use of medicinal plants to treat different illness and symptoms. One of the most commonly used plant used is Matricaria chamomilla or chamomille which is a traditional plant with digestive activity and others effects test partially as antinflammatory and anesthetic that need to continue being studied. The presence of polyphenols in the hydroalcoholic extract suggests the ability to block signal transduction pathways like Mitogen Activated Protein Kinases (MAPK), this could have an important implication in the activation of the immune cells such as macrophages also strengthen the ability to react to external agents to organism. In this work we tested the effects of exposure to one hour of the chamomille hidroalcoholic extract in the J774 cell line and its effects in the viability, bacterial phagocytosis and the pathway activation of MAPK, ERK 1/2‐P. Preliminary results show that the viability of macrophages did not affected in one hour but decrease at the 6 hours of the expose, the phagocytosis of bacteria increase slightly to 5 % and ERK 1/2 expression has not change expression but phosphorylation of ERK 1/2 decrease importantly. Our preliminary conclusions are that the chamomile extract induce sensibility in phagocytosis to bacteria without affect its the viability but decreasing the MAPK pathway activation. Support or Funding Information PROMEP UASLP‐DSA/103.5/14/11016 and FAI‐UASLP