The Effects of Bioactive Food Ingredients Alone or In Combination With Protein Supplement On Metabolism, Thermogenesis, Body Fat, Body Weight And Appetite

• Published in: The FASEB journal 2016-04, Vol.30 (S1)
• Main Authors: Brock, Paula Vieira, Vaughan, Brent, Vollmer, David
• Format: Article
• Language: English
• ISSN: 0892-6638; 1530-6860
• DOI: 10.1096/fasebj.30.1_supplement.lb376

Abstract only According to the 2009–2010 Center for Disease Control and Prevention survey, 69% of adults in the United States are overweight. Recent research has revealed that thermogenic compounds and other natural food ingredients may stimulate the sympathetic nervous system and promote satiety, thermogenesis, and fat loss. However, the combination of natural extracts containing these bioactive compounds has not been studied. Furthermore, published research on our patent‐pending protein supplement revealed significant effects on biomarkers of fat burning, metabolism and satiety. Due to this potential synergistic effect of protein and thermogenic compounds, in the current investigation our novel supplement containing the above mentioned bioactive food ingredients was tested alone and in combination with our patent‐pending protein supplement. First, twelve mice were placed on 60% fat diet for 8 d and subsequently divided into a low, medium and high‐dose groups and vehicle. Animals received the novel supplement by oral gavage daily for 5 d. No observable adverse event was noted. In a subsequent study, C57BL/6J mice (n=10) were placed on a 60% high‐fat diet at 4 weeks of age. At 8 weeks of age, animals were randomly assigned to receive oral daily dosing of vehicle, the novel supplement alone or with our patent‐pending protein supplement. The following measures of metabolism, thermogenesis, body fat and appetite were collected before and after 4 weeks of treatment: energy expenditure, adiponectin, leptin and insulin in blood, surface body temperature, UCP1 protein in brown adipose tissue, body composition, body weight, and food consumption. Findings will be discussed. Support or Funding Information Source of Research Support: 4Life Research, LLC