Naloxone does not antagonize general anesthesia in the rat

The administration of naloxone 2, 10, 50, or 250 mg/kg intravenously did not alter halothane requirement (MAC) in Sprague-Dawley rats (12 per group). Two rats convulsed when given 50 mg/kg while anesthetized with halothane. In a separate group of awake rats, seven of nine animals convulsed when give...

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Bibliographic Details
Published in:Anesthesiology (Philadelphia) 1978-07, Vol.49 (1), p.3-5
Main Authors: Harper, M H, Winter, P M, Johnson, B H, Eger, 2nd, E I
Format: Article
Language:English
Subjects:
Anesthesia, Inhalation
Animals
Dose-Response Relationship, Drug
Enkephalins - metabolism
Halothane - administration & dosage
Halothane - adverse effects
Halothane - antagonists & inhibitors
Naloxone - administration & dosage
Naloxone - adverse effects
Naloxone - pharmacology
Rats
Seizures - chemically induced
Spirometry
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Summary:The administration of naloxone 2, 10, 50, or 250 mg/kg intravenously did not alter halothane requirement (MAC) in Sprague-Dawley rats (12 per group). Two rats convulsed when given 50 mg/kg while anesthetized with halothane. In a separate group of awake rats, seven of nine animals convulsed when given naloxone, 100 mg/kg. It is concluded that any effect of naloxone on anesthetic requirement must be small (not significant in our study), and that if an effect exists it is the result of a nonspecific analeptic action of naloxone rather than a specific action at opiate receptors.
ISSN:0003-3022
DOI:10.1097/00000542-197807000-00002