The influence of salt-concentration on hæmolysis

The question of the effect of salt-concentration on the phenomena involved in haemolysis has already received a considerable amount of attention. Nolf originally showed that the presence of certain salts, in definite concentrations, inhibited haemolysis, and his observations have been repeatedly con...

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Bibliographic Details
Published in:Proceedings of the Royal Society of London. Series B, Containing papers of a biological character Containing papers of a biological character, 1915-03, Vol.88 (605), p.396-408
Main Author: Topley, William Whiteman Carlton
Format: Article
Language:English
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Summary:The question of the effect of salt-concentration on the phenomena involved in haemolysis has already received a considerable amount of attention. Nolf originally showed that the presence of certain salts, in definite concentrations, inhibited haemolysis, and his observations have been repeatedly confirmed. Markl, working with acid sodium phosphate, showed that the introduction of this salt into a haemolytic mixture caused complete inhibition of haemolysis when a certain concentration was reached. He was also able to show that the presence of this salt did not prevent the combination of the antibody with the red cells. He therefore concluded that its action consisted in so influencing the osmotic relations of the cell membrane that the complement could not be fixed upon it. He found that this action was not specific for acid sodium phosphate, but could be observed with other salts, notably with hypertonic solutions of sodium chloride itself.
ISSN:0950-1193
2053-9185
DOI:10.1098/rspb.1915.0003