The Development of Indicator-Dilution Techniques

After 87 years, Stewart's fundamental conceptual contribution, the indicator-dilution method for measuring blood flow, is still the basis for a variety of common, practical, and minimally invasive clinical techniques. Given the spectrum of available indicators and their corresponding sensing te...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 1984-12, Vol.BME-31 (12), p.800-807
Main Authors: Trautman, Edwin D., Newbower, Ronald S.
Format: Article
Language:English
Subjects:
Anesthesia
Animals
Biomedical engineering
Biomedical measurements
Blood flow
Body Water - analysis
Dogs
Fluid flow measurement
Hospitals
Humans
Indicator Dilution Techniques
Lung - analysis
Mathematics
Minimally invasive surgery
Models, Theoretical
Thermal conductivity
Thermal engineering
Thermodilution
Volume measurement
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Summary:After 87 years, Stewart's fundamental conceptual contribution, the indicator-dilution method for measuring blood flow, is still the basis for a variety of common, practical, and minimally invasive clinical techniques. Given the spectrum of available indicators and their corresponding sensing techniques, we review the relevant transport theory and required assumptions. Various previous developments in the theory of flow and volume measurement are brought together in a formal restatement, based on the general case of dilution of volume indicators, rather than just the special case of mass indicators. The importance of each of the required assumptions is evaluated. Examples discussed include the use of conductivity modifiers and thermal indicators, with and without pulsatile flow. The formalism developed is intended to be helpful in assessing the opportunities and limitations associated with any proposed new indicator-dilution application.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.1984.325241