Black Phosphorus-Based Surface Plasmon Resonance Biosensor for DNA Hybridization

In this work, we proposed and performed the numerical analysis of novel surface plasmon resonance (SPR) biosensor architecture (Prism-BAK1/Ag/WS2/Ni/BP/SM) based on angular interrogation at a wavelength of 633 nm. At minimum reflectance ( R_{\mathrm {min}} ) value, the remarkable sensitivity and fig...

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Bibliographic Details
Published in:IEEE transactions on plasma science 2024-04, Vol.52 (4), p.1358-1365
Main Authors: Kumar, Rajeev, Singh, Shivam, Chaudhary, Bhargavi, Kumar, Santosh
Format: Article
Language:English
Subjects:
Biosensor
Biosensors
black phosphorus
Deoxyribonucleic acid
DNA
DNA hybridization
Figure of merit
Hybridization
Interrogation
Metals
Nickel
Nucleotides
Numerical analysis
Polymorphism
Reflectivity
Refractivity
Resonance
Sensitivity
Surface plasmon resonance
surface plasmon resonance (SPR)
Surface plasmons
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Summary:In this work, we proposed and performed the numerical analysis of novel surface plasmon resonance (SPR) biosensor architecture (Prism-BAK1/Ag/WS2/Ni/BP/SM) based on angular interrogation at a wavelength of 633 nm. At minimum reflectance ( R_{\mathrm {min}} ) value, the remarkable sensitivity and figure of merit (FoM) of 198.15°/RIU and 64.79/RIU are attained at a refractive index (RI) range of 1.33-1.41 for the sensing medium (SM). Additionally, the performance parameters of the SPR biosensor are meticulously measured in relation to FoM, sensitivity, limit of detection (LoD), and detection accuracy (DA) concerning the concentration of complementary target DNA hybridization in the SM. The maximum sensitivity is achieved with DNA hybridization. Notably, the probe and mismatch DNA hybridization demonstrate the maximum sensitivities of 379.69°/RIU and 383.01°/RIU, respectively. Thus, this structure-based SPR biosensor can distinguish between single nucleotide polymorphism (SNP) and DNA hybridization. In the realm of biomedicine, this adaptable biosensor holds great potential for the detection of life-threatening diseases through DNA hybridization.
ISSN:0093-3813
1939-9375
DOI:10.1109/TPS.2024.3386399