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SNP s in candidate genes MX dynamin‐like GTP ase and chemokine ( C ‐ C motif) receptor‐5 are associated with ovine pulmonary adenocarcinoma progression in Latxa sheep

Ovine pulmonary adenocarcinoma ( OPA ) is a contagious lung cancer in sheep caused by Jaagsiekte sheep retrovirus ( JSRV ). OPA is present in many sheep‐rearing countries causing economic and welfare issues, as currently no efficient vaccines or treatments are available. Breed differences suggest a...

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Bibliographic Details
Published in:Animal genetics 2015-12, Vol.46 (6), p.666-675
Main Authors: Larruskain, A., Esparza‐Baquer, A., Minguijón, E., Juste, R. A., Jugo, B. M.
Format: Article
Language:English
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Summary:Ovine pulmonary adenocarcinoma ( OPA ) is a contagious lung cancer in sheep caused by Jaagsiekte sheep retrovirus ( JSRV ). OPA is present in many sheep‐rearing countries causing economic and welfare issues, as currently no efficient vaccines or treatments are available. Breed differences suggest a host genetic component may influence the pathogenesis of OPA , but so far few genes have been identified. In this work, a genetic association study was carried out in Latxa dairy sheep which were classified as cases/controls based on the presence/absence of OPA lung tumours. Candidate genes included cytokines and a receptor and innate immunity genes. After SNP s in the candidate genes were identified, the distribution of alleles in cases and controls was compared by means of logistic regression analyses at the allelic, genotypic and haplotypic levels. The association analysis showed that several candidate genes were significantly associated with resistance or susceptibility to OPA ; two of the candidates, CCR 5 and MX 1 , remained significantly associated with resistance and susceptibility respectively, even after Bonferroni correction.
ISSN:0268-9146
1365-2052
DOI:10.1111/age.12351