Leukemogenesis via aberrant self‐renewal by the MLL/AEP‐mediated transcriptional activation system

Homeostasis of the hematopoietic system is achieved in a hierarchy, with hematopoietic stem cells at the pinnacle. Because only hematopoietic stem cells (HSCs) can self‐renew, the size of the hematopoietic system is strictly controlled. In hematopoietic reconstitution experiments, 1 HSC can reconsti...

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Bibliographic Details
Published in:Cancer science 2021-10, Vol.112 (10), p.3935-3944
Main Author: Yokoyama, Akihiko
Format: Article
Language:English
Subjects:
Bone marrow
Cell activation
Cell division
Cell self-renewal
DNA-directed RNA polymerase
Genes
Granulocytes
Growth factors
Hematopoietic stem cells
Histone H3
Histones
Homeostasis
Leukemia
Leukemogenesis
molecular therapy
Mutation
Progenitor cells
Promoters
Proteins
Review
RNA polymerase
self‐renewal
Stem cells
Transcription activation
transcriptional machinery
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