AIM2 upregulation promotes metastatic progression and PD‐L1 expression in lung adenocarcinoma

Cancer metastasis leading to the dysfunction of invaded organs is the main cause of the reduced survival rates in lung cancer patients. However, the molecular mechanism for lung cancer metastasis remains unclear. Recently, the increased activity of inflammasome appeared to correlate with the metasta...

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Bibliographic Details
Published in:Cancer science 2023-01, Vol.114 (1), p.306-320
Main Authors: Zheng, Jing‐Quan, Lin, Che‐Hsuan, Lee, Hsun‐Hua, Chang, Wei‐Ming, Li, Li‐Jie, Su, Chia‐Yi, Lee, Kang‐Yun, Chiu, Hui‐Wen, Lin, Yuan‐Feng
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma of Lung - pathology
AIM2 inflammasome
Apoptosis
B7-H1 Antigen - genetics
B7-H1 Antigen - metabolism
Breast cancer
cancer metastasis
Cell culture
Cell death
Comparative analysis
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
epithelial‐mesenchymal transition
Gene expression
Genomes
Humans
Immune checkpoint
Inflammasomes
Inflammasomes - metabolism
Lung cancer
Lung Neoplasms - pathology
Medical prognosis
Melanoma
Metastases
Metastasis
Original
ORIGINAL ARTICLES
PD-L1 protein
PD‐L1
Prognosis
Proteins
RNA
RNA, Messenger - genetics
Stat1 protein
Statistical significance
Tumorigenesis
Tumors
Up-Regulation
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