New insights on chromatin modifiers and histone post-translational modifications in renal cell tumours

Renal cell tumours (RCTs) are the most common neoplasms affecting the kidney. They are clinically, pathologically and genetically heterogeneous, comprises four major histological subtypes [clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (pRCC) and chromophobe renal cell carci...

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Bibliographic Details
Published in:European journal of clinical investigation 2015-01, Vol.45 (s1), p.16-24
Main Authors: Vieira-Coimbra, Márcia, Henrique, Rui, Jerónimo, Carmen
Format: Article
Language:English
Subjects:
Adenoma, Oxyphilic - genetics
Adenoma, Oxyphilic - metabolism
Carcinoma, Renal Cell - genetics
Carcinoma, Renal Cell - metabolism
Chromatin - metabolism
Chromatin modifiers
Epigenesis, Genetic
Epigenetic biomarkers
Epigenetic modulators
Epigenetic modulators, Epigenetic biomarkers
Epigenetic-target therapy
Histone covalent modifications
Histone covalent modifications, Chromatin modifiers
Histones - metabolism
Humans
Kidney Neoplasms - genetics
Kidney Neoplasms - metabolism
Protein Processing, Post-Translational - genetics
Renal cell tumours
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Summary:Renal cell tumours (RCTs) are the most common neoplasms affecting the kidney. They are clinically, pathologically and genetically heterogeneous, comprises four major histological subtypes [clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (pRCC) and chromophobe renal cell carcinoma (chRCC), which are malignant tumours, and oncocytoma, a benign tumour], as well as an increasing number of less common entities. Epigenetics has emerged as an important field in oncology due to the critical role it plays in neoplastic transformation and progression. Among epigenetic mechanisms, the modulation of chromatin packaging through covalent modifications is fundamental for gene transcription regulation and its deregulation is involved in carcinogenesis. Recently, deregulation of chromatin machinery in RCTs has increasingly acknowledged as an important mechanism for renal neoplastic transformation. The aim of this review is to summarize the most relevant alterations in histone post‐translational modifications and chromatin modifiers, which have been implicated in renal tumorigenesis. The recognition of those modifications might provide new biomarkers for diagnosis and prognostication as well as novel targets for personalized therapeutic intervention.
ISSN:0014-2972
1365-2362
DOI:10.1111/eci.12360