Antitumor necrosis factor alpha and an epidural abscess during a spinal cord stimulator trial: A case report

• Published in: Pain practice 2022-01, Vol.22 (1), p.113-116
• Main Authors: Frazier, Andrew, Orr, Walter N., Braun, Edward
• Format: Article
• Language: English
• Subjects: epidural abscess; Epidural Abscess - drug therapy; Epidural Abscess - etiology; Humans; low back pain; Necrosis; Spinal Cord; spinal cord stimulation; Spinal Cord Stimulation - adverse effects; Tumor Necrosis Factor Inhibitors
• ISSN: 1530-7085; 1533-2500
• DOI: 10.1111/papr.13025

Spinal cord stimulation (SCS) is commonly utilized for treatment and management of chronic intractable low back and lower extremity pain. Although SCS is an overall low‐risk procedure, there are potential life‐threatening complications, including surgical site infections, such as an epidural abscess. Immunosuppression, a risk factor for epidural abscess, is becoming more common as an increasing number of patients are being treated with biologics for a multitude of autoimmune disorders. One class of commonly utilized biologics is antitumor necrosis factor (anti‐TNF) alpha. Whereas these drugs can provide tremendous benefit for treatment and management of autoimmune disorders, there is no clear understanding of the degree to which these medications increase a patient’s risk for surgical site infection, including those associated with SCS‐related procedures. We present a case of an epidural abscess that developed immediately following an SCS trial in a patient with multiple undisclosed risk factors, including the use of an anti‐TNF alpha agent to treat ankylosing spondylitis. For an epidural abscess, early diagnosis is key to preventing devastating complications and the need for surgical intervention. Immunosuppression can be the result of multiple issues including cancer, HIV, and biologic agents, such as anti‐TNF alpha for the management of autoimmune diseases. There is limited evidence pertaining to the development of epidural abscesses in patients on anti‐TNF alpha medications who undergo SCS. Studies focused on infections in patients undergoing SCS trials and permanent implants while on anti‐TNF alpha agents could provide recommendations and guidance.