Hyperproliferation of Elschnig pearl‐type posterior capsule opacification and spontaneous regression in two pseudophakic canine eyes

• Published in: Veterinary ophthalmology 2024-03, Vol.27 (2), p.170-176
• Main Authors: Lee, Eunji, Kim, Hyun‐ah, Seo, Kangmoon, Kang, Seonmi
• Format: Article
• Language: English
• Subjects: after cataract; cataract surgery; lens epithelial cells; lens‐induced uveitis; phacoemulsification; regeneratory PCO
• ISSN: 1463-5216; 1463-5224
• DOI: 10.1111/vop.13173

Objective To describe the hyperproliferation of Elschnig pearl‐type posterior capsule opacification and concurrent uveitis in two canine eyes after phacoemulsification, followed by spontaneous resolution of the Elschnig pearls. Animal Studied A 10‐year‐old castrated male Spitz (Case 1) and a 4‐year‐old spayed female Bichon Frise (Case 2). Procedure Elschnig pearls proliferating beyond the anterior capsulotomy site were observed in the right eye 10 months after bilateral diabetic cataract surgery (Case 1) and 7 months after unilateral cataract surgery (Case 2). In both cases, hyperproliferation occurred where the anterior capsule did not overlap with the intraocular lens (IOL), and was accompanied by aqueous flare. In Case 1, the pearls extended from the anterior capsule and adhered to the iris, causing focal posterior synechia. No other possible causes of uveitis were apparent. Results Initially, uveitis severity improved after the administration of topical and systemic anti‐inflammatory drugs. However, uveitis recurred when the dosage of anti‐inflammatory treatment was reduced. The Elschnig pearls underwent morphological changes throughout the follow‐up period. In both cases, the pearls beyond the anterior capsulotomy resolved spontaneously after 5 months. Only a few pearls remained between the IOL and posterior capsule, and no recurrence of pearl proliferation was observed at the last follow‐up. Conclusions To the best of our knowledge, this is the first report of spontaneous Elschnig pearl regression in dogs. Lens‐induced uveitis (LIU) may have been caused by anterior chamber hyperproliferative pearls. LIU associated with hyperproliferative pearls may be managed with appropriate anti‐inflammatory treatment and monitoring.