Bone metastases induce metabolic changes and mitophagy in mice

New Findings What is the central question of this study? Cachexia causes severe changes in skeletal muscle metabolism and function and is a key predictor of negative outcomes in cancer patients: what are the changes in whole animal energy metabolism and mitochondria in skeletal muscle? What is the m...

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Bibliographic Details
Published in:Experimental physiology 2021-02, Vol.106 (2), p.506-518
Main Authors: Wilcox‐Hagerty, Jenna, Xu, Haifang, Hain, Brian A., Arnold, Amy C., Waning, David L.
Format: Article
Language:English
Subjects:
Animals
Bone cancer
Bone Neoplasms - metabolism
Bone Neoplasms - secondary
Breast cancer
Cachexia
Cachexia - metabolism
Cachexia - pathology
Calorimetry
Energy expenditure
Energy metabolism
Energy Metabolism - physiology
Female
Mammary Neoplasms, Experimental - metabolism
Mammary Neoplasms, Experimental - pathology
Metabolism
Metastases
Metastasis
Mice
Mitochondria
Mitochondria, Muscle - metabolism
Mitophagy
Mitophagy - physiology
Muscle, Skeletal - metabolism
Musculoskeletal system
Organelle Biogenesis
Proteins
Skeletal muscle
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