Stimulation-Produced Analgesia: Development of Tolerance and Cross-Tolerance to Morphine

Analgesia resulting from focal electrical stimulation of the brain of the rat shows tolerance with repeated exposures; this tolerance dissipates after a period of non-stimulation. Addiction to morphine reduces greatly the analgesia produced by electrical stimulation of the brain, which demonstrates...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1975-05, Vol.188 (4191), p.941-943
Main Authors: Mayer, David J., Hayes, Ronald L.
Format: Article
Language:English
Subjects:
Analgesia
Analgesics
Animals
Brain - drug effects
Brain damage
Cytochalasins
Dose-Response Relationship, Drug
Drug Tolerance
Electric Stimulation
Electrical stimulation
Electrodes
Electrodes, Implanted
Humans
Male
Mesencephalon - physiology
Morphine
Morphine - pharmacology
Morphine Dependence
Muscle fibers
Myoblasts
Rats
Stereotaxic Techniques
T tests
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Summary:Analgesia resulting from focal electrical stimulation of the brain of the rat shows tolerance with repeated exposures; this tolerance dissipates after a period of non-stimulation. Addiction to morphine reduces greatly the analgesia produced by electrical stimulation of the brain, which demonstrates cross-tolerance between morphine analgesia and stimulation-produced analgesia. Recovery of the stimulation-produced analgesia is seen after discontinuing administration of morphine. These results suggest that morphine and electrical stimulation produce analgesia by common mechanisms. The fact that tolerance occurs to the analgesic effect of electrical stimulation indicates that tolerance may be an alteration of an endogenous neuronal process.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1094537