The Role of T$_H$1 and T$_H$2 Cells in a Rodent Malaria Infection

CD4$^+$ T cells play a major role in protective immunity against the blood stage of malaria, but the mechanism of protection is unclear. By adoptive transfer of cloned T cell lines, direct evidence is provided that both T$_H$1 and T$_H$2 subsets of CD4$^+$ T cells can protect mice against Plasmodium...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1993-06, Vol.260 (5116), p.1931-1934
Main Authors: Taylor-Robinson, Andrew W., Phillips, R. Stephen, Severn, Alison, Moncada, Salvador, Liew, Foo Y.
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Infections
Isotypes
Malaria
Mice
Nitrates
Parasitemia
Spleen cells
T lymphocytes
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Summary:CD4$^+$ T cells play a major role in protective immunity against the blood stage of malaria, but the mechanism of protection is unclear. By adoptive transfer of cloned T cell lines, direct evidence is provided that both T$_H$1 and T$_H$2 subsets of CD4$^+$ T cells can protect mice against Plasmodium chabaudi chabaudi infection. T$_H$1 cells protect by a nitric oxide-dependent mechanism, whereas T$_H$2 cells protect by the enhancement and accelerated production of specific immunoglobulin G1 antibody.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.8100366