Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

Secretion of the cytokine interleukin-1β (IL-1β) by macrophages, a major driver of pathogenesis in atherosclerosis, requires two steps: Priming signals promote transcription of immature IL-1β, and then endogenous "danger" signals activate innate immune signaling complexes called inflammaso...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2015-07, Vol.349 (6245), p.316-320
Main Authors: Warnatsch, Annika, Ioannou, Marianna, Wang, Qian, Papayannopoulos, Venizelos
Format: Article
Language:English
Subjects:
Amplification
Atherosclerosis
Cholesterol
Crystals
Cytokines
Immunology
Macrophages
Pathogenesis
Secretions
T cell receptors
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