MitoCPR—A surveillance pathway that protects mitochondria in response to protein import stress

The import of proteins into mitochondria is essential for cell viability. How cells respond when mitochondrial protein import is impaired is poorly understood. Weidberg and Amon showed that upon mitochondrial import stress, yeast cells mounted a response known as the mitoCPR. mitoCPR was activated w...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) 2018-04, Vol.360 (6385)
Main Authors:	Weidberg, Hilla, Amon, Angelika
Format:	Article
Language:	English
Subjects:	Accumulation Adenosine Adenosine triphosphatase Adenosine Triphosphatases - metabolism Amino acids Autophagy-Related Proteins - metabolism Biodegradation Channels Chaperones Cytosol Defects Degradation Deoxyribonucleic acid DNA Drug resistance Electron transport Gene expression Heme Imports Lipid metabolism Lipids Localization Metabolites Mitochondria Mitochondria - metabolism Mitochondrial DNA Mitochondrial Membrane Transport Proteins - metabolism Multidrug resistance Nuclei Peptidyl Transferases - metabolism Precursors Proteasome Endopeptidase Complex - metabolism Proteasomes Protein folding Protein Transport Proteins Proteolysis Proteomes Respiratory failure Respiratory function Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Signaling Stress, Physiological Stresses Sulfur Surveillance Translocase Triphosphatase Yeast
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