Antiamyloid properties of fullerene C60 derivatives

A comparative estimation of the ability of complexes of fullerene C 60 with polyvinylpyrrolidone and fullerene C 60 derivatives (the sodium salt of the polycarboxylic derivative of fullerene C 60 , sodium fullerenolate), has been carried out. The fullerenes destroyed amyloid fibrils of the Aβ(1–42)...

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Bibliographic Details
Published in:Biophysics (Oxford) 2012-05, Vol.57 (3), p.300-304
Main Authors: Bobylev, A. G., Shpagina, M. D., Bobyleva, L. G., Okuneva, A. D., Piotrovsky, L. B., Podlubnaya, Z. A.
Format: Article
Language:English
Subjects:
Biological and Medical Physics
Biophysics
Molecular Biophysics
Physics
Physics and Astronomy
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Summary:A comparative estimation of the ability of complexes of fullerene C 60 with polyvinylpyrrolidone and fullerene C 60 derivatives (the sodium salt of the polycarboxylic derivative of fullerene C 60 , sodium fullerenolate), has been carried out. The fullerenes destroyed amyloid fibrils of the Aβ(1–42) peptide of the brain and the muscle X-protein. A study of the effect of fullerenes on muscle actin showed that complexes of fullerene C 60 with polyvinylpyrrolidone and sodium fullerenolate did not prevent the filament formation of actin, nor did they destroy its filaments in vitro. Conversely, sodium salt of the polycarboxylic derivative of fullerene C 60 destroyed actin filaments and prevented their formation. It was concluded that sodium fullerenolate and complexes of fullerene C 60 with polyvinylpyrrolidone are the most effective antiamyloid compounds among the fullerenes examined.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350912030050