A water-soluble aromatic dendrimer as a model basis for dual-action drugs

The affinities of two anionic pyrenyl probes for pyridinium high-molecular-mass cations of different topologies—poly( N -ethyl-4-vinylpyridinium bromide) and a water-soluble poly(pyridylphenylene) dendrimer—are studied by the method of fluorescence quenching. The hydrophilic probe carrying three sul...

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Bibliographic Details
Published in:Polymer science. Series A, Chemistry, physics Chemistry, physics, 2011-08, Vol.53 (8), p.698-706
Main Authors: Zhiryakova, M. V., Kuchkina, N. V., Shifrina, Z. B., Izumrudov, V. A.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Polyelectrolytes
Polymer Sciences
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Summary:The affinities of two anionic pyrenyl probes for pyridinium high-molecular-mass cations of different topologies—poly( N -ethyl-4-vinylpyridinium bromide) and a water-soluble poly(pyridylphenylene) dendrimer—are studied by the method of fluorescence quenching. The hydrophilic probe carrying three sulfonate groups in a molecule more efficiently interacts with a flexible highly charged linear polycation throughout the studied pH range. The binding of the dendrimer with a relatively hydrophobic probe containing a single carboxyl group is improved by acidification of solutions, and it becomes dominant in weakly acidic solutions. The interaction of DNA with the dendrimer containing the hydrophobic probe has no effect on the formation of the dendriplex and leads to displacement of only a small fraction of the bound probe into solution. Our model studies demonstrate that dual-action dendrimer carriers capable of simultaneous delivery of genetic material and hydrophobic drugs to target cells can be created.
ISSN:0965-545X
1555-6107
DOI:10.1134/S0965545X1108013X