Cyclocondensation of N-aryl-3-oxobutanethioamides with 1H-1,2,4-triazol-5-amine

Reactions of N -aryl-3-oxobutanethioamides with 1 H -1,2,4-triazole-5-amine give mixtures of 7-arylamino-5-methyl[1,2,4]triazolo[1,5- a ]pyrimidines, 5-methyl-4,7-dihydro[1,2,4]triazolo[1,5- a ]pyrimidine-7-thione, 7-methyl-4,5-dihydro[1,2,4]triazolo[1,5- a ]pyrimidine-5-thione, and 5-arylamino-7-me...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2008-10, Vol.44 (10), p.1528-1531
Main Author: Britsun, V. N.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
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Summary:Reactions of N -aryl-3-oxobutanethioamides with 1 H -1,2,4-triazole-5-amine give mixtures of 7-arylamino-5-methyl[1,2,4]triazolo[1,5- a ]pyrimidines, 5-methyl-4,7-dihydro[1,2,4]triazolo[1,5- a ]pyrimidine-7-thione, 7-methyl-4,5-dihydro[1,2,4]triazolo[1,5- a ]pyrimidine-5-thione, and 5-arylamino-7-methyl[1,2,4]triazolo[ 1,5- a ]pyrimidines whose ratio depends on the substituent in the aryl group of initial N -aryl-3-oxobutanethioamide and solvent nature (the presence of a proton-donor solvent).
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428008100229