Iodocyclization of 6-allylamino-4,5-dihydropyrazolo[3,4-d]pyrimidines

6-Allylamino-1-R-4,5-dihydro-1 H -pyrazolo[3,4- d ]pyrimidines treated with iodine in the presence of potassium carbonate are converted into 6-allylamino-1-R-1 H -pyrazolo[3,4- d ]pyrimidines that at further reaction with iodine undergo the cyclization into 6-iodomethyl-1-R-1,6,7,8-tetrahydroimidazo...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2012-05, Vol.48 (5), p.713-720
Main Authors: Vas’kevich, R. I., Bentya, A. V., Turov, A. V., Rusanov, E. B., Staninets, V. I., Vovk, M. V.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
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Summary:6-Allylamino-1-R-4,5-dihydro-1 H -pyrazolo[3,4- d ]pyrimidines treated with iodine in the presence of potassium carbonate are converted into 6-allylamino-1-R-1 H -pyrazolo[3,4- d ]pyrimidines that at further reaction with iodine undergo the cyclization into 6-iodomethyl-1-R-1,6,7,8-tetrahydroimidazo [1,2- a ]pyrazolo[3,4- d ]-pyrimidin-5-ium iodide of a linear structure. In the absence of potassium carbonate alongside the mentioned linear products 8-iodo-methyl-1-R-1,4,5,6,7,8-hexahydroimidazo[1,2- a ]pyrazolo[4,3- e ] pyrimidin-9-ium iodides of an angular structure have been obtained.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428012050144