Exploring Mitochondrial Quality in Aging and Neurodegenerative Diseases

Aging is a gradual process characterized by a decline in cellular and tissue function, significantly contributing to the development and progression of neurodegenerative diseases. Research emphasizes the crucial role of mitochondrial quality control (MQC) in the face of reactive oxygen species (ROS)...

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Bibliographic Details
Published in:Neurochemical journal 2024-09, Vol.18 (3), p.406-414
Main Authors: Xin Jiao, Li, Meiyu, Na, Donghui, Meng, Meng, Zhang, Guohui, Guo, Ying
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Neurosciences
Review Articles
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Summary:Aging is a gradual process characterized by a decline in cellular and tissue function, significantly contributing to the development and progression of neurodegenerative diseases. Research emphasizes the crucial role of mitochondrial quality control (MQC) in the face of reactive oxygen species (ROS) during aging. MQC encompasses mitochondrial fission and fusion, mitochondrial biogenesis, and mitochondrial degradation, including mitophagy and mitochondrial-derived vesicles (MDVs). These components are potentially degraded in lysosomes or released to extracellular space via multivesicular bodies (MVB). Evidence has shown malfunction in MQC under oxidative stress heightens the risk of aging and age-related neurodegenerative diseases, such as Alzheimer’s disease, Amyotrophic lateral sclerosis, and Parkinson’s disease. However, the precise mechanisms of disrupted MQC during aging remain unclear. This review aims to delve into the discussion of disrupted MQC modulation in aging and explore ways to expand lifespan and mitigate the onset of age-related neurodegenerative diseases.
ISSN:1819-7124
1819-7132
DOI:10.1134/S1819712424700016