Stem cells and microenvironment: Integration of biochemical and mechanical factors

The role of the microenvironment in the regulation of the main stem cell functions is considered. Special attention is paid to the effects of mechanical interactions and mechanical properties of the substrate on self-renewal, maintenance of potency, and differentiation in stem cells in vivo and in v...

Full description

Saved in:
Bibliographic Details
Published in:Biology bulletin reviews 2014-07, Vol.4 (4), p.263-275
Main Authors: Kostyushev, D. S., Simirskii, V. N., Song, S., Paltsev, M. A., Gnatenko, D. A., Suchkov, S. V.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Cell Biology
Ecology
Life Sciences
Zoology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The role of the microenvironment in the regulation of the main stem cell functions is considered. Special attention is paid to the effects of mechanical interactions and mechanical properties of the substrate on self-renewal, maintenance of potency, and differentiation in stem cells in vivo and in vitro. Primary cilia, mechanosensitive channels, receptors coupled with G proteins, and the proteins of intercellular junctions can be mechanosensors. In turn, the major role in mechanotransduction belongs to integrins, a large family of extracellular matrix receptors. Integrins are part of focal adhesions. They form bridges to link the cell membrane to the cytoskeleton and nucleus. The study of the integration of the biochemical and mechanical factors of the microenvironment is essential for the introduction of stem cell technology into regenerative medicine.
ISSN:2079-0864
2079-0872
DOI:10.1134/S2079086414040069