Embracing Complexity: What Novel Sequencing Methods Are Teaching Us About Herpesvirus Genomic Diversity

The arrival of novel sequencing technologies throughout the past two decades has led to a paradigm shift in our understanding of herpesvirus genomic diversity. Previously, herpesviruses were seen as a family of DNA viruses with low genomic diversity. However, a growing body of evidence now suggests...

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Bibliographic Details
Published in:Annual review of virology 2024-06, Vol.11 (1), p.67-87
Main Authors: Ortigas-Vasquez, Alejandro, Szpara, Moriah
Format: Article
Language:English
Subjects:
deep sequencing
genomics
haplotype reconstruction
herpesviruses
long-read sequencing
quasispecies
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Summary:The arrival of novel sequencing technologies throughout the past two decades has led to a paradigm shift in our understanding of herpesvirus genomic diversity. Previously, herpesviruses were seen as a family of DNA viruses with low genomic diversity. However, a growing body of evidence now suggests that herpesviruses exist as dynamic populations that possess standing variation and evolve at much faster rates than previously assumed. In this review, we explore how strategies such as deep sequencing, long-read sequencing, and haplotype reconstruction are allowing scientists to dissect the genomic composition of herpesvirus populations. We also discuss the challenges that need to be addressed before a detailed picture of herpesvirus diversity can emerge.
ISSN:2327-056X
2327-0578
2327-0578
DOI:10.1146/annurev-virology-100422-010336