Relative contribution of vasodilator prostanoids and NO to metabolic vasodilation in the human forearm

Centre for Heart and Chest Research, Monash Medical Centre and Monash University, Melbourne, Australia Although many factors are thought to contribute to the regulation of metabolic vasodilation in skeletal muscle vasculature, recent interest has focused on the role of the endothelium. We examined t...

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Published in:American journal of physiology. Heart and circulatory physiology 1999-02, Vol.276 (2), p.H663-H670
Main Authors: Duffy, Stephen J, New, Gishel, Tran, Binh T, Harper, Richard W, Meredith, Ian T
Format: Article
Language:English
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Summary:Centre for Heart and Chest Research, Monash Medical Centre and Monash University, Melbourne, Australia Although many factors are thought to contribute to the regulation of metabolic vasodilation in skeletal muscle vasculature, recent interest has focused on the role of the endothelium. We examined the relative roles of nitric oxide (NO) and of vasodilator prostanoids in the control of metabolically induced functional hyperemia in the forearm of humans. In 43 healthy volunteers [24   ± 5 (SD) yr] we assessed resting and functional hyperemic blood flow (FHBF) in response to 2 min of isotonic forearm exercise before and after inhibition of NO and/or vasodilator prostanoid production with intra-arterial N G -monomethyl- L -arginine ( L -NMMA, 2 mg/min) and aspirin (ASA, 3   mg/min), respectively. Blood flow was measured using venous occlusion plethysmography. L -NMMA and ASA decreased resting forearm blood flow by 42% ( P  
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.1999.276.2.H663