Cocaine administration induces human splenic constriction and altered hematologic parameters

1  Brain Imaging Center, 2  Alcohol and Drug Abuse Research Center, and 3  Department of Medicine, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478 Cocaine is a potent vasoconstrictor that has been shown to alter hemoglobin, hematocrit, and red blood cell counts in both animals...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 1998-11, Vol.85 (5), p.1877-1883
Main Authors: Kaufman, Marc J, Siegel, Arthur J, Mendelson, Jack H, Rose, Stephanie L, Kukes, Thellea J, Sholar, Michelle B, Lukas, Scott E, Renshaw, Perry F
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood
Blood Cells - drug effects
Circulatory system
Cocaine
Cocaine - pharmacology
Dopamine Uptake Inhibitors - pharmacology
Female
Hematocrit
Hemodynamics - drug effects
Hemoglobins - metabolism
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Neuropharmacology
NMR
Nuclear magnetic resonance
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Spleen - anatomy & histology
Spleen - drug effects
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Summary:1  Brain Imaging Center, 2  Alcohol and Drug Abuse Research Center, and 3  Department of Medicine, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478 Cocaine is a potent vasoconstrictor that has been shown to alter hemoglobin, hematocrit, and red blood cell counts in both animals and humans. The present study evaluated whether cocaine administration induces splenic constriction in men and whether spleen-volume changes temporally correlate with altered hematologic parameters. Spleen volume was assessed at baseline and after cocaine administration (0.4 mg/kg) by using magnetic resonance imaging. A group of five healthy men, aged 31 ± 2 (SE) yr and reporting occasional cocaine use (13 ± 5 lifetime exposures), participated. Cocaine reduced spleen volume by 20 ± 4% ( P  
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.1998.85.5.1877