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DNA Stability and Serum Selenium Levels in a High-Risk Group for Prostate Cancer
The essential micronutrient, selenium, is at low levels in the New Zealand diet. Selenium is a component of a number of proteins involved in the maintenance of genomic stability, and recommended daily allowances (RDA) are set on saturation levels for glutathione peroxidase (GPx), a key enzyme in sur...
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Published in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2004-03, Vol.13 (3), p.391-397 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The essential micronutrient, selenium, is at low levels in the New Zealand diet. Selenium is a component of a number of proteins
involved in the maintenance of genomic stability, and recommended daily allowances (RDA) are set on saturation levels for
glutathione peroxidase (GPx), a key enzyme in surveillance against oxidative stress. It has been assumed but not proven that
this level will be adequate for other key selenoenzymes. The “Negative Biopsy Trial” identifies a group of New Zealand individuals
at high risk of prostate cancer, whose serum selenium levels will be monitored and who will be supplemented with a yeast-based
tablet, with or without selenium, over an extended time. Access to patients on this trial provides the opportunity to ask
the more generic question as to whether selenium levels in this population are adequate to maintain genomic stability. The
single cell gel electrophoresis (comet) assay was used to study DNA damage in blood leukocytes harvested from these volunteers.
Average serum selenium levels before randomization was 97.8 ± 16.6 ng/ml, low by international standards. For the half of
the population below this mean value, lower serum selenium levels showed a statistically significant inverse relationship
( P = 0.02) with overall accumulated DNA damage. Although other interpretations cannot be excluded, the data suggest that the
selenium intake in half of this population is marginal for adequate repair of DNA damage, increasing susceptibility to cancer
and other degenerative diseases. It also raises the question as to whether glutathione peroxidase saturation levels are appropriate
indicators of the optimal selenium levels for a given population. |
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ISSN: | 1055-9965 1538-7755 |
DOI: | 10.1158/1055-9965.391.13.3 |