DNA Damage in Patients Infected by Helicobacter pylori

Helicobacter pylori ( H. pylori ) is considered to predispose carriers to gastric cancer but its role on gastric carcinogenesis is still unknown. The aim of this study was to investigate DNA damage by the comet assay in gastric epithelial cells from antrum and corpus in H. pylori -infected patients...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2004-04, Vol.13 (4), p.631-637
Main Authors: LADEIRA, Marcelo S. P, RODRIGUES, Maria A. M, SALVADORI, Daisy M. F, QUEIROZ, Dulciene M. M, FREIRE-MAIA, Dértia V
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Biological and medical sciences
Brazil - epidemiology
Case-Control Studies
Child
Child, Preschool
Comet Assay
DNA Damage
DNA Primers
Esophagus
Female
Gastritis - blood
Gastritis - epidemiology
Gastritis - microbiology
Gastritis - pathology
Gastroenterology. Liver. Pancreas. Abdomen
Helicobacter Infections - blood
Helicobacter Infections - epidemiology
Helicobacter Infections - microbiology
Helicobacter Infections - pathology
Helicobacter pylori
Humans
Leukocytes
Male
Medical sciences
Middle Aged
Polymerase Chain Reaction
Prospective Studies
Stomach Neoplasms - microbiology
Tumors
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Summary:Helicobacter pylori ( H. pylori ) is considered to predispose carriers to gastric cancer but its role on gastric carcinogenesis is still unknown. The aim of this study was to investigate DNA damage by the comet assay in gastric epithelial cells from antrum and corpus in H. pylori -infected patients with gastritis of different degrees. H. pylori status, gastric histology, and DNA damage were studied in 62 H. pylori -infected and 18 non-infected patients, all of them non-smokers, non-alcoholics, and non-drug users. DNA damage was significantly higher in H. pylori -infected patients presenting gastritis than in non-infected patients with normal mucosa. A direct correlation between the levels of DNA damage and the intensity of gastritis was observed in H. pylori -infected patients. Association between DNA damage and age was also found. The levels of DNA damage were significantly higher in patients older than 50 years than in younger patients with the same degree of gastritis. Our results indicate that H. pylori infection is associated with DNA damage in gastric epithelial cells, which could be a biomarker of risk for gastric cancer in humans.
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.631.13.4