Abstract 5492: The effects of whole body hyperthermia on tumor growth by a novel far infrared emitter

• Published in: Cancer research (Chicago, Ill.) Ill.), 2010-04, Vol.70 (8_Supplement), p.5492-5492
• Main Authors: Uemura, Hirotsugu, Ushida, Hiroshi, Asahi, Chiori, Miyazaki, Yuka, Yoshikawa, Kazuhiro, De Velasco, Marco A.
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM10-5492

Whole body hyperthermia (WBH) has been used alone or as an adjunct to radio- and/or chemotherapy for the treatment of various malignant diseases. The therapeutic effect of WBH in these conditions has been hypothesized to involve direct or indirect activation of the immune system and heat shock proteins (HSPs). In this study, we investigate the effects of hyperthermia in vitro and in vivo using BioRubber (BR, Yamamoto Bio-Technology Inc., Anaheim, CA), a revolutionary far infrared emitter on tumor growth. BR is a pliable state-of-the-art biomaterial that emits FIR in the 4-25μm spectral ranges. For the in vitro experiments, cell growth assays and cell cycle analysis was performed in a total of twelve different cancer cell lines (HeLa, bladder, prostate and renal) sandwiched between BR. BR had no inhibitory effects on any of the tumor cells grown in vitro. To determine the effects of BR therapy on tumor and normal tissue in vivo, KU7/GFP-bearing nude mice were housed in cages lined with BR for 28 days. Tumor size and core body temperature were recorded weekly. The core body temperatures of mice exposed to BR increased significantly by 1oC (P