Abstract 3142: Expression of C-X-C motif chemokine 10 (CXCL10) in breast cancer

• Published in: Cancer research (Chicago, Ill.) Ill.), 2011-04, Vol.71 (8_Supplement), p.3142-3142
• Main Authors: Sivik, Tove, Kot, Agnieszka, Stål, Olle, Fornander, Tommy, Skoog, Lambert, Nordenskjöld, Bo, Jansson, Agneta
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM2011-3142

Chemokines are small cytokine-like secreted proteins with chemoattractant properties which function in the recruitment of leucocytes into inflamed tissue. Besides well studied roles in the immune system, chemokines and their receptors have also been shown to play critical roles in tumorigenesis. The present study focuses on C-X-C motif chemokine 10 (CXCL10), a potent chemoattractant for stimulated T-cells and NK-cells. Both CXCL10 and its receptor CXCR3 are expressed by breast tumor cells, and accumulating data suggests roles for this chemokine and its receptor in breast cancer development and proliferation. We have previously shown CXCL10 to be significantly upregulated in ER positive as well as negative breast cancer cell lines over-expressing 17β hydroxysteroid dehydrogenase 14 (17βHSD14). Using a validated anti-CXCL10 primary antibody, we examined the relationship between CXCL10 expression and clinicopathological features in tissue microarrays comprised of tumor material from 912 breast cancer patients participating in a randomized tamoxifen trial conducted in Stockholm, Sweden, 1976-1990. All patients had lymph node negative primary breast cancer and were postmenopausal at the time of diagnosis. Results were obtained from tumors of 793 patients, of which 6% were deemed negative, 23% weak, 28% moderate, and 42% strong. Staining intensity of CXCL10 was strongly correlated with expression of 17βHSD14 (p