Abstract 2066: The functional noncoding genome in childhood sarcomas plays important regulatory roles in tumor pathogenesis

• Published in: Cancer research (Chicago, Ill.) Ill.), 2018-07, Vol.78 (13_Supplement), p.2066-2066
• Main Authors: Mitra, Sheetal A., Mitra, Anirban P., Liu, Yang, Buckley, Jonathan D., Triche, Timothy J.
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM2018-2066

Pediatric soft tissue sarcomas such as rhabdomyosarcomas (RMS) and Ewing sarcomas (ES) occur in children and adolescents. These tumors typically have a very primitive stem cell-like appearance with few mutations, thus underscoring the importance of other genetic and epigenetic mechanisms responsible for initiating and maintaining tumorigenesis. Noncoding RNAs (ncRNA) are known to play an important role in development and cancer and hence we hypothesized that they would regulate the genomes of these developmental sarcomas. Whole-transcriptome profiling was performed on primary tumors from 200 ES, and 80 RMS patients. Cox regression models were used to generate prognostic metafeatures (MF) for the RMS cohort. A 30-protein-coding MF (pcMF, p= 0.001) and a 34-noncoding MF (ncMF, p