Abstract 2077: Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients

• Published in: Cancer research (Chicago, Ill.) Ill.), 2018-07, Vol.78 (13_Supplement), p.2077-2077
• Main Authors: Koster, Roelof, Panagiotou, Orestis A., Wheeler, William A., Karlins, Eric, Gastier-Foster, Julie M., Toledo, Silvia Regina Caminada de, Petrilli, Antonio S., Flanagan, Adrienne M., Tirabosco, Roberto, Andrulis, Irene L., Wunder, Jay S., Gokgoz, Nalan, Patiño-Garcia, Ana, Lecanda, Fernando, Serra, Massimo, Hattinger, Claudia, Picci, Piero, Scotlandi, Katia, Thomas, David M., Ballinger, Mandy L., Gorlick, Richard, Barkauskas, Donald A., Spector, Logan G., Tucker, Margaret, Hicks, Belynda, Yeager, Meredith, Hoover, Robert, Chanock, Stephen J., Savage, Sharon A., Mirabello, Lisa J.
• Format: Article
• Language: English
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM2018-2077

Survival rates for osteosarcoma, the most common primary bone cancer, have changed little over the past three decades and are particularly low for patients with metastatic disease. To date, few prognostic factors have been identified to be associated with survival in patients with osteosarcoma. We conducted an international, multi-institutional genome-wide association study (GWAS) to identify germline genetic variants associated with overall survival in 632 patients with osteosarcoma. Subjects were genotyped as part of our previously published osteosarcoma susceptibility GWAS, including 523 patients of >80% European ancestry and 109 patients from Brazil. We performed a time-to-event analysis and estimated hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazards models, with and without adjustment for metastatic disease. Cox models were adjusted for age at diagnosis, gender, significant principal components, and study/center. SNPs that reached P