Abstract C127: Delays in penile cancer presentation and undertreatment may drive higher penile cancer mortality in Latinos and older men in California

• Published in: Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2020-06, Vol.29 (6_Supplement_1), p.C127-C127
• Main Authors: Nabhani, Jamal, Baccaglini, Willy, Medina, Luis, Sotelo, Rene, Liu, Lihua, Deapen, Dennis, Stern, Mariana C.
• Format: Article
• Language: English
• ISSN: 1055-9965; 1538-7755
• DOI: 10.1158/1538-7755.DISP18-C127

Background: Penile cancer, although relatively rare, has a 5-year survival rate of approximately 50% and carries a considerable physical and psychological burden due to penile resections needed for its treatment at more advanced stages. We evaluated the racial/ethnic, sociodemographic, and corresponding clinical and treatment patterns among men diagnosed with penile cancer in California. Methods: We used data from the California Cancer Registry between 1998-2012. We performed logistic regression to evaluate the likelihood of presenting with a high-risk primary tumor (pathologic tumor stage 2 or greater), receipt of radical surgery (partial or radical penectomy controlling for cancer stage), and receipt of chemotherapy (controlling for cancer stage). Finally, we performed a survival analysis using a cox proportional-hazard model controlling for sociodemographic and clinical features. Results: We included 3,201 cases of penile cancer. Of those, 2,107 (65.8%) were non-Latino White (NLW), 731 (22.8%) were Latinos, 160 (5%) were non-Latino Black (NLB), and 203 (6.34%) were Asian Pacific Islanders (API). Age-adjusted incidence rates were 1.29 for NLW, 1.25 for NLB, 1.45 for Latinos, and 0.67 for API. In the high-risk tumor analysis, Latinos were two times more likely to present with locally advanced disease in comparison with NLW (OR 2.04, 1.46-2.86, p